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Association between polymorphisms in OAS2 and CD209 genes and predisposition to chronic hepatitis C in Russian population.

Authors
  • Barkhash, Andrey V1
  • Kochneva, Galina V2
  • Chub, Elena V2
  • Mikhailova, Svetlana V3
  • Romaschenko, Aida G3
  • 1 Laboratory of Human Molecular Genetics, Institute of Cytology and Genetics, Russian Academy of Sciences, Siberian Branch, 10 Lavrentyeva Ave., Novosibirsk 630090, Russia. Electronic address: [email protected]
  • 2 Laboratory of Viral Hepatitis, State Research Center of Virology and Biotechnology "Vector", Koltsovo, Novosibirsk Region(1) 630559, Russia.
  • 3 Laboratory of Human Molecular Genetics, Institute of Cytology and Genetics, Russian Academy of Sciences, Siberian Branch, 10 Lavrentyeva Ave., Novosibirsk 630090, Russia.
Type
Published Article
Journal
Microbes and infection
Publication Date
May 01, 2014
Volume
16
Issue
5
Pages
445–449
Identifiers
DOI: 10.1016/j.micinf.2014.02.004
PMID: 24594345
Source
Medline
Keywords
License
Unknown

Abstract

Chronic hepatitis C is a severe liver disease caused by positive-strand RNA virus. Previously, we reported an association between seven single nucleotide polymorphisms (SNPs) in four innate immunity genes (OAS2, OAS3, CD209, and TLR3) and human predisposition to tick-borne encephalitis, caused by a virus from the same Flaviviridae family, in a Russian population. Currently, genotype and allele frequencies for these SNPs were analyzed in 75 chronic hepatitis C patients and compared with the population control (269 Novosibirsk citizens). Data obtained suggest that the OAS2 rs1293762 and CD209 rs2287886 SNPs are associated with predisposition to chronic hepatitis C in Russian population.

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