Affordable Access

deepdyve-link
Publisher Website

Association between polymorphisms in microRNAs and susceptibility to diabetes mellitus: A meta-analysis.

Authors
  • Chen, Xi1
  • Wang, Wenjing2
  • Li, Ruien1
  • Yu, Jing1
  • Gao, Lei3
  • 1 Endocrine Metabolic Disease Section.
  • 2 Anorectal Department, the Affiliated Hospital to Changchun University of Chinese Medicine.
  • 3 College of Basic Medicine, Changchun University of Chinese Medicine, Changchun, Jilin Province, China. , (China)
Type
Published Article
Journal
Medicine
Publisher
Ovid Technologies (Wolters Kluwer) - Lippincott Williams & Wilkins
Publication Date
Nov 01, 2019
Volume
98
Issue
44
Identifiers
DOI: 10.1097/MD.0000000000017519
PMID: 31689753
Source
Medline
Language
English
License
Unknown

Abstract

Accumulated evidence has indicated the associations between single-nucleotide polymorphisms (SNPs) in microRNAs (miRNAs) and the susceptibility to diabetes mellitus (DM), but the conclusions remain controversial. This study was to investigate the true contribution of miRNA SNPs to the risk of DM by using a meta-analysis of all the published studies. Relevant studies were identified in the databases of PubMed and the Cochrane Library databases. The strength of associations between miRNA polymorphisms and DM risk was assessed by odds ratios (ORs) and 95% confidence intervals (95% CIs) under five genetic models using the STATA software. Six studies, containing 2773 cases and 2632 controls, were enrolled, 5 of which evaluated miR-146a (rs2910164), 4 for miR-27a (rs895819), and 3 for miR-124 (rs531564) and 2 for miR-375 (rs6715345), miR-128a (rs11888095), miR-194a (rs3820455). The meta-analysis indicated that the G allele or GG genotype of miR-146a rs2910164 was associated with a significantly increased risk for DM compared with C allele or GC/CC genotype in Latin American population; CC genotype of miR-27a rs895819 polymorphism was associated with a significantly decreased risk for DM in Asian population compared with the TT genotype; patients carrying with CC genotype of miR-124 rs531564 had a lower probability to develop DM regardless of ethnicity; no associations were identified between polymorphisms in miR-375, miR-128a, miR-194a and the susceptibility to DM. Our study suggests that miR-146a/miR-27a and miR-124 polymorphisms may be ethnicity-dependent or -independent susceptibility factors to DM, respectively.

Report this publication

Statistics

Seen <100 times