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Association Between Polycystic Ovary Syndrome and the Polymorphisms of Aryl Hydrocarbon Receptor Repressor, Glutathione-S-transferase T1, and Glutathione-S-transferase M1 Genes.

Authors
  • Chung, Youn Kyung1
  • Kim, Jin Ju2, 3, 4
  • Hong, Min A2
  • Hwang, Kyu Ri2, 5
  • Chae, Soo Jin6
  • Yoon, Sang Ho6
  • Choi, Young Min2, 4
  • 1 Department of Obstetrics and Gynecology, National Cancer Center, Goyang, Korea. , (North Korea)
  • 2 Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Korea. , (North Korea)
  • 3 Department of Obstetrics and Gynecology, Healthcare System Gangnam Center, Seoul National University Hospital, Seoul, Korea. , (North Korea)
  • 4 The Institute of Reproductive Medicine and Population, Medical Research Center, Seoul National University College of Medicine, Seoul, Korea. , (North Korea)
  • 5 Department of Obstetrics and Gynecology, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, Seoul, Korea. , (North Korea)
  • 6 Department of Obstetrics and Gynecology, IORA Fertility Clinic, Suwon, Korea. , (North Korea)
Type
Published Article
Journal
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology
Publication Date
Jun 01, 2021
Volume
37
Issue
6
Pages
558–561
Identifiers
DOI: 10.1080/09513590.2020.1832066
PMID: 33124502
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

To investigate the association between the aryl hydrocarbon receptor repressor (AhRR) C/G polymorphisms and glutathione-S-transferase M1 (GSTM1) and GSTT1 null mutation and the risk of polycystic ovary syndrome (PCOS) in Korean women. This was a case-control study of 478 women with PCOS and 376 aged-matched healthy controls. Genotyping of the AhRR C/G polymorphism and GSTM1 and GSTT1 were performed using real-time PCR analysis and multiplex PCR, respectively. The genotype distribution of the AhRR C/G polymorphisms and GSTM1/GSTT1 null mutations did not differ between women with PCOS and controls. Using the wild-type combined AhRR CC and GSTT1 present genotype as a reference, the odds that a woman had PCOS were 1.54 (95% CIs 1.04-2.29) times higher if she had a combined AhRR CG or GG and GSTT1 null genotype. The odds that a woman had PCOS was 1.48 (95% CIs 1.08-2.04) times higher if she had a combined GSTM1/GSTT1 null genotype compared with the wild-type combined GSTM1/GSTT1 present genotype. However, there were no significant associations between the risk of PCOS and any combined AhRR and GSTM1. Our data suggest that a combined AhRR CG or GG and GSTT1 null genotype or a combined GSTT1/GSTM1 null genotype might be associated with an increased risk of PCOS.

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