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Association between personality profile and subclinical atherosclerosis: The role of genes and environment.

Authors
  • Medda, Emanuela1
  • Fagnani, Corrado2
  • Alessandri, Guido3
  • Baracchini, Claudio4
  • Hernyes, Anita5
  • Lucatelli, Pierleone6
  • Pucci, Giacomo7
  • Tarnoki, Adam D5
  • Tarnoki, David L5
  • Stazi, Maria Antonietta8
  • 1 Centre for Behavioural Sciences and Mental Health, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy. Electronic address: [email protected] , (Italy)
  • 2 Centre for Behavioural Sciences and Mental Health, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy. Electronic address: [email protected] , (Italy)
  • 3 Department of Psychology, University of Rome "Sapienza", Via dei Marsi 78, 00185 Rome, Italy. Electronic address: [email protected] , (Italy)
  • 4 Department of Neuroscience, University of Padua School of Medicine, Via Giustiniani 5, 35128 Padua, Italy. , (Italy)
  • 5 Medical Imaging Centre, Semmelweis University, Üllői út 26, H-1085 Budapest, Hungary. , (Hungary)
  • 6 Department of Radiological Oncological and Anatomo-Pathological Sciences, University of Rome "Sapienza", Viale del Policlinico 155, 00161 Rome, Italy. , (Italy)
  • 7 Department of Medicine, University of Perugia, Piazzale Tristano di Joannuccio, 1, Terni, Italy. , (Italy)
  • 8 Centre for Behavioural Sciences and Mental Health, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy. Electronic address: [email protected] , (Italy)
Type
Published Article
Journal
International journal of cardiology
Publication Date
Oct 01, 2020
Volume
316
Pages
236–239
Identifiers
DOI: 10.1016/j.ijcard.2020.05.034
PMID: 32442593
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

The mechanism underlying the association between personality profile and subclinical atherosclerosis is poorly understood. This study explores the association between personality, carotid atherosclerosis and arterial stiffness, and the contribution of genes and environment to this association. Early atherosclerotic traits, including carotid intima-media thickness (CCA-IMT), aortic pulse wave velocity (PWVao) and heart rate, were assessed in 318 adult twins, who also completed a Big Five personality questionnaire. Using the co-twin control approach, the association between intra-pair differences in clinical and personality scores was assessed in dizygotic (DZ) and monozygotic (MZ) twins separately. An association between CCA-IMT and extroverted personality, as well as between PWVao and openness to experience was detected. The inverse association between CCA-IMT and extraversion was persistent in DZ and disappeared in MZ twins, suggesting genetic confounding. In contrast, the association between PWVao and openness to experience was of the same magnitude in DZ and MZ twins, thus surviving the adjustment for genetic and shared environmental factors. This study highlights that the association between some psychological factors and cardiovascular traits may be partly explained by genetic factors. This result may provide support for the feasibility of prevention programs based on assessing familiarity for personality disorders to detect genetic risk for subclinical cardiovascular disease. Copyright © 2020 Elsevier B.V. All rights reserved.

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