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Association between NMD3 and symptoms of Parkinson’s disease in Chinese patients

Authors
  • Wu, Hui1
  • Li, Hui1
  • Shi, Zhiqiang1
  • Tang, Jiajia1
  • Mei, Shuya1
  • Ai, Tianyi1
  • He, Zhenzhou1
  • 1 Shanghai Jiaotong University, 2000 Jiangyue Road, Shanghai, 201112, China , Shanghai (China)
Type
Published Article
Journal
BMC Neurology
Publisher
Springer (Biomed Central Ltd.)
Publication Date
Jan 14, 2020
Volume
20
Issue
1
Identifiers
DOI: 10.1186/s12883-019-1574-1
Source
Springer Nature
Keywords
License
Green

Abstract

BackgroundParkinson’s disease (PD) is a progressive neurodegenerative movement disorder that is characterized by motor symptoms such as tremor, rigidity, slowness of movement and problems with gait. Large-scale meta-analyses of genome-wide association studies (GWAS) have identified few susceptibility loci in patients with sporadic PD. The aim of this study was to investigate the association between NMD3 single nucleotide polymorphism (SNP) and symptoms in PD patients in South China.MethodsA total of 217 PD patients were recruited in this study and genotyped by using the SNaPshot technique and the polymerase chain reaction. All subjects were evaluated by the Mini-Mental State Examination (MMSE), Beijing version Montreal Cognitive Assessment (MoCA), Sniffin’ Sticks 16 (SS-16), Hamilton Anxiety Rating Scale, Hamilton Depression Rating Scale, 39-item Parkinson’s Disease Questionnaire (PDQ-39) and MDS Unified PD Rating Scale (MDS-UPDRS).ResultsNMD3 rs34016896 (C > T) carriers have worse cognitive function than wild types (MMSE: p = 0.042, NMD3 wild type: 27.44 ± 2.89, NMD3 carriers: 26.31 ± 3.79; MoCA: p = 0.005, NMD3 wild type: 23.15 ± 4.20, NMD3 carriers: 20.75 ± 6.68).ConclusionsThe recessive and overdominant model of NMD3 rs34016896 was associated with cognitive impairment in PD patients.

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