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Association between miR-146aG>C and miR-196a2C>T polymorphisms and the risk of hepatocellular carcinoma in a Chinese population.

Authors
  • Zhou, Bing1
  • Dong, Liang-Peng
  • Jing, Xiao-Yue
  • Li, Jin-Song
  • Yang, Shu-Juan
  • Wang, Jun-Ping
  • Zhao, Long-Feng
  • 1 Department of General Surgery, The First Affiliated Hospital of Xinxiang Medical University, Weihui, 453100, China, [email protected] , (China)
Type
Published Article
Journal
Tumor Biology
Publisher
SAGE Publications
Publication Date
Aug 01, 2014
Volume
35
Issue
8
Pages
7775–7780
Identifiers
DOI: 10.1007/s13277-014-2020-z
PMID: 24816919
Source
Medline
License
Unknown

Abstract

MicroRNAs have been demonstrated to have a role in susceptibility and prognosis of various types of human cancer. We investigated the association between polymorphisms in miR-146aG>C, miR-196a2C>T, and miR-499A>G and hepatocellular carcinoma (HCC) risk and interaction with HCC and hepatitis B virus (HBV) infection. Two hundred sixty-six cases with HCC and 281 health controls were enrolled in the present study. Genotyping of the miR-146aG>C, miR-196a2C>T, and miR-499A>G genotypes was conducted by duplex polymerase chain reaction with the confronting two-pair primer (PCR-RFLP). Subjects with miR-146a GG and G allele had an increased risk of HCC compared with the homozygote CC genotype. Similarly, HCC patients carrying microRNA (miRNA)-196a2 computed tomography, TT, and T allele significantly decreased the risk of HCC relative to the CC genotype. Stratified analysis indicated that miR-196a2C>T polymorphism was associated with reduced risk of HBV-related HCC, but not in hepatitis C virus- and nonviral-related HCC cases. In conclusion, miR-146aG>C and miR-196a2C>T polymorphism are associated with risk of HCC patients in China, especially in patients with HBV infection. SNPs in miRNA sequences can be used as a diagnostic biomarker for HCC.

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