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Association between metabolic syndrome and knee osteoarthritis: a cross-sectional study

Authors
  • Xie, Dong-xing1
  • Wei, Jie2, 3
  • Zeng, Chao1
  • Yang, Tuo1
  • Li, Hui1
  • Wang, Yi-lun1
  • Long, Hui-zhong1
  • Wu, Zi-ying1
  • Qian, Yu-xuan1
  • Li, Kang-hua1
  • Lei, Guang-hua1
  • 1 Central South University, Department of Orthopaedics, Xiangya Hospital, #87 Xiangya Road, Changsha, Hunan, 410008, People’s Republic of China , Changsha (China)
  • 2 Central South University, Health Management Center, Xiangya Hospital, Changsha, Hunan Province, 410008, People’s Republic of China , Changsha (China)
  • 3 Central South University, Department of Epidemiology and Health Statistics, Xiangya School of Public Health, Changsha, Hunan Province, 410008, People’s Republic of China , Changsha (China)
Type
Published Article
Journal
BMC Musculoskeletal Disorders
Publisher
Springer (Biomed Central Ltd.)
Publication Date
Dec 16, 2017
Volume
18
Issue
1
Identifiers
DOI: 10.1186/s12891-017-1890-9
Source
Springer Nature
Keywords
License
Green

Abstract

BackgroundOsteoarthritis (OA) is the most prevalent chronic joint disease in China. The aim of this study was to examine the association between metabolic syndrome (MetS) and knee OA in a population-based Chinese study.MethodsData included in this analysis is from a cross-sectional study, i.e., the Xiangya Hospital Health Management Center Study. MetS was diagnosed according to the criteria defined by the Chinese Diabetes Society. Radiographic knee OA was defined as changes equivalent to Kellgren-Lawrence (K-L) grade 2 or above at least one side. Associations between MetS and its components with OA were evaluated by conducting multivariable adjusted logistic regression.ResultsA total of 5764 participants were included in the present study. The unadjusted OR (1.27, 95%CI: 1.10–1.47, P = 0.001), age-sex adjusted OR (1.17, 95%CI: 1.01–1.36, P = 0.041) and multivariable adjusted OR (1.17, 95%CI: 1.01–1.36, P = 0.043) all suggested a positive association between MetS and knee OA. Besides, its components (e.g., overweight, hypertension and dyslipidemia) were also associated with the prevalence of radiographic knee OA respectively, after adjusting for some confounding factors. In addition, with the accumulation of MetS components, the prevalence of knee OA increased. Furthermore, MetS as a whole was associated with the prevalence of knee osteophyte (OSP) (OR = 1.72, 95%CI: 1.42–2.09, P < 0.001), but not joint space narrowing (JSN) (OR = 1.06, 95%CI: 0.91–1.23, P = 0.449).ConclusionsThe findings of the present study indicated that there was a positive association between the prevalence of MetS and knee OA. However, MetS as a whole was associated with the higher prevalence of knee OSP, but not JSN, which should shed light on our understanding the association between MetS and OA.

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