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Association between Inflammation-Based Parameters and Prognosis in Patients with Acute Kidney Injury

Authors
  • hyelim, ju
  • min, sunyoung
  • park, minsu
Publication Date
Sep 05, 2021
Identifiers
DOI: 10.3390/medicina57090936
OAI: oai:mdpi.com:/1648-9144/57/9/936/
Source
MDPI
Keywords
Language
English
License
Green
External links

Abstract

Background and Objectives: this study aimed to clarify the relationship between inflammation-based parameters and prognosis in patients with acute kidney injury (AKI). Materials and Methods: We analyzed the prospectively collected data of patients with AKI, who were admitted through the emergency department between March 2020 and April 2021. Their clinical characteristics, inflammation-based parameters, resolving/non-resolving AKI pattern, and major adverse kidney event (MAKE) rates were analyzed. Results: Among 177 patients, 129 (72.9%) had a resolving AKI pattern and 48 (27.1%) had a non-resolving AKI pattern. The outcome of MAKE occurred in 30 (16.9%) participants. Multivariate analyses showed that the neutrophil-to-monocyte ratio was an independent predictor of resolving AKI, and that the neutrophil-to-monocyte and neutrophil-to-lymphocyte ratios were independent predictors of MAKE occurrence. Conclusions: we demonstrated that inflammation-based parameters are valuable predictors of early recovery and MAKE occurrence in patients with AKI.

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