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Association between the G1246A polymorphism of the hypocretin receptor 2 gene and cluster headache: a meta-analysis.

Authors
  • Rainero, Innocenzo1
  • Rubino, Elisa
  • Valfrè, Walter
  • Gallone, Salvatore
  • De Martino, Paola
  • Zampella, Erika
  • Pinessi, Lorenzo
  • 1 Neurology II-Headache Centre, Department of Neuroscience, University of Turin, Via Cherasco 15, I-10126 Turin, Italy. [email protected] , (Italy)
Type
Published Article
Journal
The journal of headache and pain
Publication Date
Jun 01, 2007
Volume
8
Issue
3
Pages
152–156
Identifiers
PMID: 17563843
Source
Medline
License
Unknown

Abstract

The objective of this study was to investigate the association between polymorphisms of the hypocretin receptor 2 gene (HCRTR2) and the risk of cluster headache (CH). The study is a meta-analysis of published case-control studies investigating the association between polymorphisms of the HCRTR2 gene and CH. Pooled odds ratios (OR) were estimated using both random (RE) and fixed effects (FE) models. Three studies, performed in five different European countries, with 593 cases and 599 controls, were included in the study. Allele G of the G1246A HCRTR2 polymorphism was significantly associated with CH (FE OR 1.58, CI 95% 1.27-1.95; RE OR 1.55 (1.14-2.12)). Carriers of the GG genotype showed a higher disease risk compared to the remaining genotypes (FE OR 1.75, CI 95% 1.37-2.25; RE OR 1.69, CI 95% 1.11-2.58). Our data confirm that the G1246A polymorphism of the HCRTR2 gene may modulate the genetic risk for CH.

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