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The association between CD31hiEmcnhi endothelial cells and bone mineral density in Chinese women.

Authors
  • Zhu, Yong1
  • Ruan, Zhe1
  • Lin, Zhangyuan1
  • Long, Haitao1
  • Zhao, Ruibo1
  • Sun, Buhua1
  • Cheng, Liang1
  • Tang, Lanhua2
  • Xia, Zhuying3
  • Li, Changjun3
  • Zhao, Shushan4, 5
  • 1 Department of Orthopedics, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, 410008, Hunan, People's Republic of China. , (China)
  • 2 Department of Oncology, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, 410008, Hunan, People's Republic of China. , (China)
  • 3 Department of Endocrinology, Endocrinology Research Center, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, 410008, Hunan, People's Republic of China. , (China)
  • 4 Department of Orthopedics, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, 410008, Hunan, People's Republic of China. [email protected] , (China)
  • 5 National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, People's Republic of China. [email protected] , (China)
Type
Published Article
Journal
Journal of Bone and Mineral Metabolism
Publisher
Springer-Verlag
Publication Date
Nov 01, 2019
Volume
37
Issue
6
Pages
987–995
Identifiers
DOI: 10.1007/s00774-019-01000-4
PMID: 30919130
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Osteoporosis is the most common bone disease in humans. During bone remodeling, specialized blood vessels influenced by the endothelial cells (CD31hiEmcnhi, also called type H cells) are formatted to supply nutrients. Reductions in vascular supply are associated with bone loss resulting in osteoporosis. Therefore, the objective of the present study was to explore the association between the CD31hiEmcnhi endothelial cells and bone mineral density (BMD). In this prospective study, 134 Chinese women were enrolled and examined. BMD was measured by DEXA method while the percentage of CD31hiEmcnhi endothelial cells in the intertrochanteric part was measured by flow cytometry. The percentage of CD31hiEmcnhi endothelial cells in postmenopausal subjects was significantly lower compared with premenopausal women (8.7 ± 4.0% vs 13.2 ± 5.6%, P < 0.01). Meanwhile, the CD31hiEmcnhi endothelial cell levels in osteopenia and osteoporosis were significantly lower compared with subjects with normal BMD (9.84 ± 4.2% in osteopenia and 7.11 ± 3.2% in osteoporosis vs 12.7 ± 5.6% in subjects with normal T score, P < 0.01). Multiple regression analyses showed that the CD31hiEmcnhi endothelial cells level was positively associated with femur neck and total hip BMD, but not with lumbar BMD. Our study suggests a significantly positive association between CD31hiEmcnhi endothelial cells and local BMD in Chinese women. The proportion of CD31hiEmcnhi endothelial cells is a marker of bone quality and represents a potential target for treatment of bone loss.

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