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[Association between body mass index and aggressiveness of papillary thyroid carcinoma].

Authors
  • Faure, Eduardo N1
  • Soutelo, María Jimena2
  • Fritz, María Clara2
  • Martín, Ayelén2
  • Musri, Yamile2
  • Lutfi, Rubén2
  • 1 Servicio de Endocrinología, Complejo Médico Churruca-Visca. Buenos Aires, Argentina. E-mail: [email protected] , (Argentina)
  • 2 Servicio de Endocrinología, Complejo Médico Churruca-Visca. Buenos Aires, Argentina. , (Argentina)
Type
Published Article
Journal
Medicina
Publication Date
Jan 01, 2018
Volume
78
Issue
3
Pages
145–150
Identifiers
PMID: 29940539
Source
Medline
Keywords
Language
Spanish
License
Unknown

Abstract

The aim of the study was to evaluate the association of the body mass index (BMI) with the clinical-pathological characteristics and the recurrence of papillary thyroid carcinoma. The cohort consisted of 208 patients with papillary thyroid carcinoma diagnosed in 2003-2014, in Buenos Aires, Argentina. The patients were grouped according to the BMI as follows: BMI <18.5 kg/m2 (low weight); BMI ≥ 18.5 and < 25 kg/m2 (normal weight); BMI ≥ 25 and < 30 kg/m2 (overweight); BMI ≥ 30 kg/m2 (obesity). Two experienced pathologists reviewed and cross-checked all pathology specimens to confirm diagnosis, tumor characteristics and extent of the disease. All patients were followed every 6 months for 2 years, and annually thereafter. Recurrences were searched by using diagnostic imaging and histological confi rmation when necessary. Regression analysis was applied to defi ne associations of BMI with clinical, pathological, and prognosis features of the disease. A 5-point increase in BMI was significantly associated with tumor size (OR 1.21; 95% CI 1.1-1.5; p = 0.01) and greater extranodal extension in cervical metastases (OR 1.11; 95% CI 1.06-1.21; p = 0.03). The analysis of prognostic variables showed no association between increase in BMI and risk of recurrence (HR 1.11; 95% CI 0.91-1.22). In conclusion, we found that BMI relates directly with tumor size and extranodal extension, but not with recurrence.

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