Affordable Access

deepdyve-link
Publisher Website

Association between blood lead levels and blood pressures in a non-smoking healthy Korean population.

Authors
  • Lee, Kyu Rae1
  • Ko, Ki Dong2
  • Hwang, In Cheol2
  • Suh, Heuy Sun2
  • Kim, Kyoung Kon2
  • 1 Department of Family Medicine, Dong-Incheon Gil Hospital, Gachon University, Incheon, South Korea. , (North Korea)
  • 2 Department of Family Medicine, Gil Medical Centre, Gachon University, Incheon, South Korea. , (North Korea)
Type
Published Article
Journal
Postgraduate Medical Journal
Publisher
BMJ
Publication Date
Sep 01, 2017
Volume
93
Issue
1103
Pages
513–518
Identifiers
DOI: 10.1136/postgradmedj-2016-134208
PMID: 27555608
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

The Korea National Health and Nutrition Examination Survey (KNHANES) has been performed every 3 years in Korea to help prevent cardiovascular mortality in the general population. Previous studies showed an association between blood lead levels and cardiovascular mortality. In order to assess the relationship between blood lead concentration and blood pressure in the healthy general population, we investigated whether blood lead levels were related to blood pressure in a non-smoking healthy population without any known medical diseases in the 2013 KNHANES. 896 (mean age 40.55±13.83 years; body mass index 23.06±3.33 kg/m2) subjects who had no known diseases were included among 8018 subjects. Exclusion criteria were: hypertension, diabetes, hyperlipidaemia, cerebrovascular events, renal insufficiency, liver cirrhosis, thyroid dysfunction, any cardiovascular or renal disease, and any malignancy. Blood pressures were measured three times by sphygmomanometers, 5 min apart. Blood pressures were then expressed as the average between the second and third values. Height, weight, waist circumferences and blood pressure, as well as total cholesterol, high density lipoprotein cholesterol, triglycerides, low density lipoprotein cholesterol, aspartate aminotransferase (AST), alanine aminotransferase (ALT), white blood cell count and blood lead levels were measured. In addition, dietary components were analysed by 24 hour recall. The association between log blood lead levels and systolic/diastolic pressure was stronger after it was controlled for age, sex, education, body mass index (BMI), waist circumference and fasting plasma glucose (FPG) (p=0.048, 0.002). Furthermore, the association between log blood lead levels and systolic pressure (p=0.048) and diastolic pressure (p=0.002) was more evident when controlled for age, sex, education, BMI, waist circumference, FPG, AST and ALT. Blood lead levels are significant determinants of systolic and diastolic blood pressure in a healthy Korean population, irrespective of sociodemographic factors and metabolic derangements. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

Report this publication

Statistics

Seen <100 times