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Association between asthma and cardiovascular disease.

Authors
  • Wee, Jee Hye1
  • Park, Min Woo2
  • Min, Chanyang3, 4
  • Byun, Soo Hwan5
  • Park, Bumjung1
  • Choi, Hyo Geun1, 3
  • 1 Department of Otorhinolaryngology-Head & Neck Surgery, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, Korea. , (North Korea)
  • 2 Department of Otorhinolaryngology-Head & Neck Surgery, Kangdong Sacred Heart Hospital, Seoul, Korea. , (North Korea)
  • 3 Hallym Data Science Laboratory, Hallym University College of Medicine, Anyang, Korea. , (North Korea)
  • 4 Graduate School of Public Health, Seoul National University, Seoul, Korea. , (North Korea)
  • 5 Department of Oral & Maxillofacial Surgery, Dentistry, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, Korea. , (North Korea)
Type
Published Article
Journal
European Journal of Clinical Investigation
Publisher
Wiley (Blackwell Publishing)
Publication Date
Mar 01, 2021
Volume
51
Issue
3
Identifiers
DOI: 10.1111/eci.13396
PMID: 32888313
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Epidemiological studies on the association between asthma and cardiovascular disease have reported conflicting results. This cross-sectional study evaluated the association between asthma and ischaemic heart disease (IHD)/stroke in Korean adults. Data from the Korean Genome and Epidemiology Study-Health Examinees were used. Among 173 209 participants, 3162 asthmatic and 159 408 control participants were selected. Histories of asthma, IHD and stroke were obtained. Participants were categorized according to their current status of asthma management: 'well-controlled', 'being treated', and 'not being treated'. Crude and adjusted (age, gender, body mass index, income, smoking, alcohol consumption, hypertension, diabetes, dyslipidaemia and nutritional intake) odds ratios (ORs) for IHD and stroke in asthmatic patients were analysed using a multiple logistic regression model. Participants with asthma reported a significantly higher prevalence of IHD (6.0% vs 3.0%) and stroke (2.3% vs 1.4%) than those without asthma (P < .001). Asthmatic participants had a higher OR (1.46, 95% confidence interval [CI] = 1.251-1.71, P < .001) for IHD than those without asthma. The association between asthma and IHD was significant only in patients aged ≥53 years (men: adjusted OR = 1.31, 95% CI = 1.01-1.70, P = .046; women: adjusted OR = 1.64, 95% CI = 1.32-2.03, P < .001) according to age and sex and in the 'not being treated' asthma group (adjusted OR = 1.47, 95% CI = 1.14-1.91, P = .003) according to the asthma management status. Stroke was not significantly associated with asthma (adjusted OR = 1.17, 95% CI = 0.92-1.48, P = .203) in the adjusted model and all subgroup analyses. Asthma was associated with IHD, mainly in older patients and untreated asthma patients, but not with stroke. © 2020 Stichting European Society for Clinical Investigation Journal Foundation. Published by John Wiley & Sons Ltd.

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