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Association between APOE ε4 Genotype and Memory Impairment in Elderly with Normal Global Cognitive Assessment.

Authors
  • Turana, Yuda1, 2
  • Suzy Handajani, Yvonne3
  • Widjaja, Nelly T4
  • 1 Department of Neurology, Faculty of Medicine, Atma Jaya Catholic University of Indonesia, Jl. Pluit Raya No. 2, North Jakarta, Jakarta 14440, Indonesia. [email protected] , (Indonesia)
  • 2 Center of Health Research, Atma Jaya Catholic University of Indonesia, Jl. Pluit Raya No. 2, North Jakarta, Jakarta 14440, Indonesia. [email protected] , (Indonesia)
  • 3 Center of Health Research, Atma Jaya Catholic University of Indonesia, Jl. Pluit Raya No. 2, North Jakarta, Jakarta 14440, Indonesia. [email protected] , (Indonesia)
  • 4 Center of Health Research, Atma Jaya Catholic University of Indonesia, Jl. Pluit Raya No. 2, North Jakarta, Jakarta 14440, Indonesia. [email protected] , (Indonesia)
Type
Published Article
Journal
Diagnostics
Publisher
MDPI AG
Publication Date
Dec 15, 2015
Volume
5
Issue
4
Pages
615–623
Identifiers
DOI: 10.3390/diagnostics5040615
PMID: 26854173
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Early prediction using cognitive evaluation tools that are less influenced by education level is beneficial for dementia screening. This study investigated the relationship between Word List Memory Immediate Recall (WLM IR) and the Saving Score (SS) with having the APOE ε4 risk allele in the elderly with normal global cognitive assessment. A cross-sectional study on 105 subjects ≥60 years with normal MMSE scores who met inclusion criteria. Memory impairment (MI) if: WLM IR score on the third trial <8 or an SS score <80%. The majority of the subjects were female (68.6%), 65 ± 7.1 years, had undertaken formal education for <6 years (56.2%), had MI (81%), and the APOE ε4 genotype was detected in 24.8% of subjects. There was a significant relationship between APOE ε4 and lower WLMIR (p = 0.02, OR 7.92, CI 95% (1.00-62.38)). WLM IR score is lower in elderly people with the APOE ε4 despite their normal global cognitive assessment results, and these scores were not influenced by education level. Further research needs to confirm that the WLM IR can be used to screen for early dementia.

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