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Association Between Adipokines Levels with Inflammatory Bowel Disease (IBD): Systematic Reviews

Authors
  • Morshedzadeh, Nava1, 2
  • Rahimlou, Mehran3
  • Asadzadeh Aghdaei, Hamid4
  • Shahrokh, Shabnam4
  • Reza Zali, Mohammad4
  • Mirmiran, Parvin1, 2
  • 1 Shahid Beheshti University of Medical Sciences, Department of Clinical Nutrition and Dietetics, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute, 7, West Arghavan St., Farahzadi Blvd., Tehran, 1981619573, Iran , Tehran (Iran)
  • 2 Shahid Beheshti University of Medical Sciences, Nutrition and Endocrine Research Center, Research Institute for Endocrine Science, Tehran, Iran , Tehran (Iran)
  • 3 Ahvaz Jundishapur University of Medical Sciences, Nutrition and Metabolic Diseases Research Center, Ahvaz, Iran , Ahvaz (Iran)
  • 4 Shahid Beheshti University of Medical Sciences, Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Tehran, Iran , Tehran (Iran)
Type
Published Article
Journal
Digestive Diseases and Sciences
Publisher
Springer-Verlag
Publication Date
Oct 30, 2017
Volume
62
Issue
12
Pages
3280–3286
Identifiers
DOI: 10.1007/s10620-017-4806-5
Source
Springer Nature
Keywords
License
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Abstract

BackgroundA combination of genetic and environmental factors is involved in the etiology of inflammatory bowel disease (IBD). Recent studies have shown that adipocytes play a crucial role, by actively participating in systemic immune responses in IBD patients. But findings remain controversial. To the best of our knowledge, no systematic review has evaluated the roles of adipokines in IBD, considering which this systematic review was undertaken to summarize the effects of these adipokines in IBD pathogenesis.MethodsFor this review, articles published between 1980 and 2016 were identified from the PubMed, EMBASE, Scopus, and Cochrane and Google scholar databases. Thirteen articles were ultimately selected for inclusion in this systematic review.ResultsFindings of the present study indicate that some of the adipokines such as leptin, adiponectin and resistin are associated with disease severity, body composition and glucose hemostasis in IBD patients, although some of these associations are stronger than others.ConclusionsOverall findings indicate that some adipokines may play a crucial role in IBD severity or other IBD related outcomes. Further studies are recommended to confirm the results.

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