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Association between the A-2518G polymorphism in the monocyte chemoattractant protein-1 gene and insulin resistance and Type 2 diabetes mellitus.

Authors
Type
Published Article
Journal
Diabetologia
Publication Date
Volume
47
Issue
9
Pages
1574–1580
Identifiers
PMID: 15349727
Source
Medline

Abstract

In a large cohort of Caucasians, the MCP-1 G-2518 gene variant was significantly and negatively correlated with plasma MCP-1 levels and the prevalence of insulin resistance and Type 2 diabetes. These results add to recent evidence supporting a role for MCP-1 in pathologies associated with hyperinsulinaemia.

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