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The association of asthma and its subgroups with osteoporosis: a cross-sectional study using KoGES HEXA data

Authors
  • Wee, Jee Hye1
  • Min, Chanyang2, 3
  • Park, Min Woo4
  • Byun, Soo Hwan5
  • Lee, Hyo-Jeong1
  • Park, Bumjung1
  • Choi, Hyo Geun1, 2
  • 1 Hallym University Sacred Heart Hospital, 22, Gwanpyeong-ro 170 beon-gil, Dongan-gu, Anyang, 14068, Republic of Korea , Anyang (South Korea)
  • 2 Hallym University College of Medicine, Anyang, Korea , Anyang (South Korea)
  • 3 Seoul National University, Seoul, South Korea , Seoul (South Korea)
  • 4 Kangdong Sacred Heart Hospital, Seoul, South Korea , Seoul (South Korea)
  • 5 Hallym University College of Medicine, Anyang, South Korea , Anyang (South Korea)
Type
Published Article
Journal
Allergy, Asthma & Clinical Immunology
Publisher
BioMed Central
Publication Date
Sep 25, 2020
Volume
16
Issue
1
Identifiers
DOI: 10.1186/s13223-020-00482-6
Source
Springer Nature
Keywords
License
Green

Abstract

BackgroundA few studies have reported the association between asthma and osteoporosis. We aimed to analyze the association of asthma and its subgroups with osteoporosis in the Korean adult population.MethodsWe used the health examinee (HEXA) data from the Korean Genome and Epidemiology Study (KoGES) obtained between 2004 and 2016. We included 162,579 participants (n = 3,160 with asthma; n = 159,419 controls) who reported their previous histories of asthma and osteoporosis. The participants were categorized into 3 groups based on asthma management: participants who did not need further treatment due to controlled symptoms (well controlled); participants with ongoing treatment (being treated); participants who were not treated even though they had symptoms (not being treated). Multiple logistic regression analyses were used to calculate the adjusted odds ratios (aORs) with 95% confidence intervals (CIs) for osteoporosis. Subgroup analyses for age and sex were conducted.ResultsThe prevalence of osteoporosis was higher in patients with asthma (13.6%) than in controls (6.8%). In the full-adjusted model, the aORs for osteoporosis were 1.74 (95% CI 1.55–1.94, P < 0.001) in patients with asthma compared to controls. There were consistent findings across the age and sex subgroups. The aORs for osteoporosis were 1.43 (95% CI 1.10–1.86, P = 0.008) in the well-controlled asthma group; 1.55 (95% CI 1.28–1.89, P < 0.001) in the being treated asthma group; and 1.96 (95% CI 1.66–2.31, P < 0.001) in the not being treated asthma group compared to the control group.ConclusionAsthma was associated with osteoporosis in the Korean adult population. Patients with asthma not being treated showed the highest ORs for osteoporosis.

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