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Association of arginine vasopressin (AVP) promoter polymorphisms with preeclampsia.

Authors
  • Erfanian, Saiedeh1
  • Yazdanpour, Leila2
  • Javeshghani, Danesh3
  • Roustazadeh, Abazar4
  • 1 Research Center for Non-Communicable Diseases, Department of Advanced Medical Sciences and Technologies, School of Medicine, Jahrom University of Medical Sciences, Jahrom, Iran. , (Iran)
  • 2 Islamic Azad University, Arsanjan Branch, Arsanjan, Iran. , (Iran)
  • 3 Department of Physiology, Jahrom University of Medical Sciences, Jahrom, Iran. , (Iran)
  • 4 Department of Biochemistry, Department of Advanced Medical Sciences and Technologies, Research Center for Non-Communicable Diseases, Jahrom University of Medical Sciences, Jahrom, Iran. Electronic address: [email protected] , (Iran)
Type
Published Article
Journal
Pregnancy hypertension
Publication Date
Oct 05, 2019
Volume
18
Pages
122–125
Identifiers
DOI: 10.1016/j.preghy.2019.09.017
PMID: 31593833
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Preeclampsia (PE) is a disease of pregnancy characterized by early onset of maternal hypertension and proteinuria. New findings indicate that arginine vasopressin (AVP) may be a contributing factor to ignite PE. The aim of this study was to identify if there is any correlation between arginine vasopressin promoter polymorphisms and PE. Venous blood samples of 100 PE and 100 normal pregnant women were obtained for DNA extraction to identify the polymorphisms of AVP promoter by RFLP and nested-PCR techniques. rs3729965 polymorphism of PE women was detected to have significant correlation with body mass index (BMI) (P = 0.028). Statistical analysis of three polymorphisms namely rs3729965, rs61138008 and rs3761249 of preeclamptic women (PEW) and none preeclamptic pregnant women (NPEW) revealed that rs3729965 genotypic distribution was significantly different between both groups (P = 0.04). Further analysis revealed that rs3729965 CT genotype of PEW had significant correlation to their BMI (P = 0.028). Polymorphic variants located on the promoter region of AVP are associated with PE. Thus we hypothesize that allelic variation may have a role in increasing the risk of developing PE. Copyright © 2019 International Society for the Study of Hypertension in Pregnancy. Published by Elsevier B.V. All rights reserved.

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