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Association analysis of the functional Ala111Glu polymorphism of the glyoxalase I gene in panic disorder.

Authors
  • Politi, Pierluigi
  • Minoretti, Piercarlo
  • Falcone, Colomba
  • Martinelli, Valentina
  • Emanuele, Enzo
Type
Published Article
Journal
Neuroscience Letters
Publisher
Elsevier
Publication Date
Mar 27, 2006
Volume
396
Issue
2
Pages
163–166
Identifiers
PMID: 16352396
Source
Medline
License
Unknown

Abstract

The zinc metalloenzyme glyoxalase I (GLO1) is thought to play a role in anxiety disorders because a reduced brain expression of GLO1 has been associated with increased anxiety-behaviours in mice. Recently, a functional Ala111Glu polymorphism in GLO1 has been shown to result in a reduced enzyme activity. The present study tested the hypothesis that this common genetic variant could confer susceptibility to panic disorder using an Italian population sample of 162 panic disorder patients and 288 matched controls. Statistical analysis failed to show association with the overall diagnosis of the disease. However, a weak but significant association was demonstrated between this polymorphism and panic disorder without agoraphobia. While our data suggest that this polymorphism is unlikely to have a major function in the pathogenesis of panic disorder, it could play a role in the subgroup of patients without agoraphobic avoidance.

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