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Association of age with clinical features and ablation outcomes of paroxysmal supraventricular tachycardias.

Authors
  • Ávila, Pablo1, 2
  • Calvo, David3
  • Tamargo, María4, 2
  • Uribarri, Aitor2, 5
  • Datino, Tomas4, 2
  • Arenal, Angel4, 2
  • Atienza, Felipe4, 2
  • Soto, Nina4, 2
  • Fernández-Avilés, Francisco4, 2
  • González-Torrecilla, Esteban4, 2
  • 1 Cardiology Department, Hospital General Universitario Gregorio Marañón, Instituto de Investigación Sanitaria Gregorio Marañón, Universidad Complutense de Madrid, Madrid, Spain [email protected] , (Spain)
  • 2 CIBERCV, Instituto de Salud Carlos III, Madrid, Spain. , (Spain)
  • 3 Cardiology Department, Hospital Universitario Central de Asturias, Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Oviedo, Spain. , (Spain)
  • 4 Cardiology Department, Hospital General Universitario Gregorio Marañón, Instituto de Investigación Sanitaria Gregorio Marañón, Universidad Complutense de Madrid, Madrid, Spain. , (Spain)
  • 5 Cardiology Department, Hospital Universitario Vall d'Hebron, Barcelona, Spain. , (Spain)
Type
Published Article
Journal
Heart
Publisher
BMJ
Publication Date
Jun 24, 2022
Volume
108
Issue
14
Pages
1107–1113
Identifiers
DOI: 10.1136/heartjnl-2021-319685
PMID: 34635482
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

The role of age in clinical characteristics and catheter ablation outcomes of atrioventricular nodal re-entrant tachycardia (AVNRT) or orthodromic atrioventricular re-entrant tachycardia (AVRT) has been assessed in retrospective studies categorising age by arbitrary cut-offs, but contemporary analyses of age-related trends are lacking. We aimed to study the relationship of age with epidemiological, clinical features and catheter ablation outcomes of AVNRT and AVRT. We recruited 600 patients (median age 56 years, 60% female) with a confirmed diagnosis of AVNRT (n=455) or AVRT (n=145) by means of an electrophysiological study. They were interrogated for arrhythmia-related symptoms with a structured questionnaire and followed up to 1 year. We analysed age as a continuous variable using regression models and adjusting for relevant covariables. Both typical and atypical forms of AVNRT upraised with age while AVRT decreased (p<0.001 by regression). Female sex predominance in AVNRT was not observed in older patients. Overall, these tachycardias became more symptomatic with ageing despite a longer tachycardia cycle length (p<0.001) and regardless of the presence of structural heart disease, with a higher proportion of dizziness, syncope, chest pain or dyspnoea (p<0.005 for all) and a lower presence of palpitations or neck pounding (p<0.001 for both). Age was not associated with catheter ablation acute success, periprocedural complications or 1-year recurrence rates (p>0.05 for all). Age, evaluated as a continuous variable, had a significant association with the clinical profile of patients with AVNRT and AVRT. Nevertheless, catheter ablation outcomes and complications were not significantly related to patients' age. © Author(s) (or their employer(s)) 2022. No commercial re-use. See rights and permissions. Published by BMJ.

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