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Assisted reproductive technology, congenital malformations, and epigenetic disease.

Authors
  • Wilkins-Haug, Louise
Type
Published Article
Journal
Clinical Obstetrics & Gynecology
Publisher
Ovid Technologies (Wolters Kluwer) - Lippincott Williams & Wilkins
Publication Date
Mar 01, 2008
Volume
51
Issue
1
Pages
96–105
Identifiers
DOI: 10.1097/GRF.0b013e318161d25a
PMID: 18303503
Source
Medline
License
Unknown

Abstract

In the 3 decades since the birth of the first in vitro fertilization-conceived child, assisted reproduction technologies were rapidly assimilated into clinical care and are now responsible for 1% to 3% of all livebirths in North America and Europe. The rate of congenital anomalies is low (4% to 6%), though it represents a modest increase over the background rate of major malformations (3%). Additionally, emerging studies of imprinting and epigenetic conditions, those genetic disorders due to changes in DNA transcription without change in DNA sequence, suggest that the preimplantation period is vulnerable to perturbations. Review of these studies provides clinically useful information and a basis for investigations of the long-term effects of assisted reproduction technology on the children conceived.

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