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Assessment of the utility of biomarkers of osteoarthritis in the guinea pig.

Authors
  • Huebner, J L
  • Kraus, V B
Type
Published Article
Journal
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society
Publication Date
Sep 01, 2006
Volume
14
Issue
9
Pages
923–930
Identifiers
PMID: 16679035
Source
Medline
License
Unknown

Abstract

Biomarkers derived from synovial fluid are reflective of histological severity in the spontaneous model of OA in the guinea pig. The synovial fluid biomarker profiles indicated accelerated cartilage matrix turnover in the Hartley strain as early as 2 months of age, prior to evidence of histological damage. The Hartley strain also exemplified an imbalance in type II collagen metabolism and a serum cytokine/chemokine profile indicative of a pro-inflammatory state. These findings elucidate additional disease-related features in the guinea pig that have relevance to OA in humans.

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