Affordable Access

deepdyve-link
Publisher Website

Assessment of RIT2 rs12456492 association with Parkinson's disease in Mainland China.

Authors
  • Liu, Zhen-hua1
  • Guo, Ji-feng2
  • Wang, Ya-qin1
  • Li, Kai1
  • Sun, Qi-ying3
  • Xu, Qian3
  • Yan, Xin-xiang3
  • Xu, Chang-shui4
  • Tang, Bei-sha5
  • 1 Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China. , (China)
  • 2 Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China; State Key Laboratory of Medical Genetics, Changsha, Hunan, People's Republic of China; Human Key Laboratory of Neurodegenerative Disorders, Central South University, Changsha, Hunan, People's Republic of China; Neurodegenerative Disorders Research Center, Central South University, Changsha, Hunan, People's Republic of China. , (China)
  • 3 Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China; Human Key Laboratory of Neurodegenerative Disorders, Central South University, Changsha, Hunan, People's Republic of China; Neurodegenerative Disorders Research Center, Central South University, Changsha, Hunan, People's Republic of China. , (China)
  • 4 Department of Neurology, Henan Provincial People's Hospital, Zhengzhou, Henan, People's Republic of China. , (China)
  • 5 Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China; State Key Laboratory of Medical Genetics, Changsha, Hunan, People's Republic of China; Human Key Laboratory of Neurodegenerative Disorders, Central South University, Changsha, Hunan, People's Republic of China; Neurodegenerative Disorders Research Center, Central South University, Changsha, Hunan, People's Republic of China. Electronic address: [email protected] , (China)
Type
Published Article
Journal
Neurobiology of aging
Publication Date
Mar 01, 2015
Volume
36
Issue
3
Identifiers
DOI: 10.1016/j.neurobiolaging.2014.12.012
PMID: 25559334
Source
Medline
Keywords
License
Unknown

Abstract

A recent meta-analysis of genome-wide association studies in Parkinson's disease (PD) has identified the rs12456492 variant in RIT2 as a new susceptibility loci. Because the characteristics of this locus in a Han Chinese population from mainland China was still unknown, we performed a case-control replication study in this population and investigated RIT2 rs12456492 variant in a large cohort of Chinese Han individuals. In total, 933 subjects comprising 460 PD patients and 473 control subjects were genotyped. We found a significant difference in the distributions of genotype and allele between PD and control groups (genotype p = 0.008, allele p = 0.007, odds ratio = 1.296, 95% confidence interval = 1.075-1.563). This study replicates the association between rs12456492 variant and risk of developing PD in a Han Chinese population.

Report this publication

Statistics

Seen <100 times