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Assessment of the quantity of microorganisms associated with bronchiectasis in saliva, sputum and nasal lavage after periodontal treatment: a study protocol of a randomised controlled trial.

Authors
  • Pinto, Erika Horácio1
  • Longo, Priscila Larcher1
  • de Camargo, Caroline Cristina Batista2
  • Dal Corso, Simone3
  • Lanza, Fernanda De Cordoba3
  • Stelmach, Rafael4
  • Athanazio, Rodrigo4
  • Fernandes, Kristianne Porta Santos5
  • Mayer, Marcia Pinto Alves6
  • Bussadori, Sandra Kalil5
  • Mesquita Ferrari, Raquel Agnelli5
  • Horliana, Anna Carolina Ratto Tempestini...1
  • 1 Biophotonics Applied to Health Sciences, Universidade Nove de Julho, UNINOVE, São Paulo, Brazil. , (Brazil)
  • 2 School of Dentistry, Universidade Nove de Julho, UNINOVE, São Paulo, Brazil. , (Brazil)
  • 3 Rehabilitation Sciences, Universidade Nove de Julho, UNINOVE, São Paulo, Brazil. , (Brazil)
  • 4 Pulmonary Department, Heart Institute (InCor), School of Medicine, University of São Paulo, São Paulo, Brazil. , (Brazil)
  • 5 Biophotonics Applied to Health Sciences, Universidade Nove de Julho, UNINOVE, São Paulo, Brazil Rehabilitation Sciences, Universidade Nove de Julho, UNINOVE, São Paulo, Brazil. , (Brazil)
  • 6 Department of Microbiology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil. , (Brazil)
Type
Published Article
Journal
BMJ Open
Publisher
BMJ
Publication Date
Apr 15, 2016
Volume
6
Issue
4
Identifiers
DOI: 10.1136/bmjopen-2015-010564
PMID: 27084279
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

The association between periodontal disease (PD) and chronic obstructive pulmonary disease (COPD) has been widely studied, with aspiration of periodontal pathogens being one of the most accepted causal mechanisms for pulmonary exacerbation. Periodontal treatment (PT) was associated with a decrease in these exacerbations. Bronchiectasis is a pulmonary disease that has many similarities to COPD; however, there are no studies correlating this condition to PD thus far. This study will evaluate if PT reduces proinflammatory cytokines in serum and saliva, as well as halitosis and the amount of microorganisms associated with exacerbation of bronchiectasis in saliva, sputum and nasal lavage 3 months after PT. A total of 182 patients with PD and bronchiectasis will be randomly allocated to group 1 (positive control; scaling and root planing (SRP)+oral hygiene (OH)) or group 2 (experimental; SRP+photodynamic therapy+OH). After 3 months, samples of saliva, nasal lavage and sputum will be collected to determine the level of Pseudomonas aeruginosa, Staphylococcus aureus and Porphyromonas gingivalis by quantitative PCR. This protocol will determine the efficacy of PT in reducing the most likely niches of bronchiectasis exacerbation by comparing pre- and post-treatment microbiology samples. Furthermore, there will be assessment of oral halitosis and verification of inflammatory cytokines in serum and saliva. This protocol has been approved by the Research Ethics Committee of Universidade Nove de Julho. Data will be published in a peer-reviewed journal. NCT02514226. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

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