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Assessment of proarrhythmic activity of chloroquine in in vivo and ex vivo rabbit models.

Authors
  • Khobragade, Shailaja B1
  • Gupta, Pankaj
  • Gurav, Prashant
  • Chaudhari, Girish
  • Gatne, Madhumanjiri M
  • Shingatgeri, Vyas M
  • 1 Department of Drug Safety Evaluation, Ranbaxy Research Laboratories, Gurgaon, Haryana, India. , (India)
Type
Published Article
Journal
Journal of pharmacology & pharmacotherapeutics
Publication Date
Apr 01, 2013
Volume
4
Issue
2
Pages
116–124
Identifiers
DOI: 10.4103/0976-500X.110892
PMID: 23759957
Source
Medline
Keywords
License
Unknown

Abstract

The results indicated that proarrhythmic potential of chloroquine and clofilium was well evaluated in both the models; moreover, both the models can be used to assess the proarrhythmic potential of the new drug candidates.

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