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An assessment of P-glycoprotein expression and activity in peripheral blood lymphocytes of transplant candidates.

Authors
  • Vasquez, E M
  • Petrenko, Y
  • Jacobssen, V
  • Sifontis, N M
  • Testa, G
  • Sankary, H
  • Benedetti, E
Type
Published Article
Journal
Transplantation Proceedings
Publisher
Elsevier
Publication Date
Jan 01, 2005
Volume
37
Issue
1
Pages
175–177
Identifiers
PMID: 15808585
Source
Medline
License
Unknown

Abstract

CD3(+)/CD8(+) cells and NK cells, exhibited significantly increased P-gp activity compared with the other cell populations. P-gp expression is not a good correlate of P-gp activity. These findings may have important implications for the use of immunosuppressive drugs posttransplant and immune responsiveness after transplantation.

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