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An assessment of methods used in the investigation of iron status: findings in a population of young British South Asian children.

Authors
  • Hinchliffe, Roderick F1
  • Vora, Ajay J2
  • Lennard, Lynne3
  • 1 Department of Paediatric Haematology, Sheffield Children's NHS Foundation Trust, Sheffield, UK Academic Unit of Clinical Pharmacology, Department of Human Metabolism, University of Sheffield Medical School, Sheffield, UK.
  • 2 Department of Paediatric Haematology, Sheffield Children's NHS Foundation Trust, Sheffield, UK Academic Unit of Child Health, Department of Human Metabolism, University of Sheffield Medical School, Sheffield, UK.
  • 3 Academic Unit of Clinical Pharmacology, Department of Human Metabolism, University of Sheffield Medical School, Sheffield, UK.
Type
Published Article
Journal
Journal of Clinical Pathology
Publisher
BMJ
Publication Date
Apr 01, 2016
Volume
69
Issue
4
Pages
345–351
Identifiers
DOI: 10.1136/jclinpath-2015-203301
PMID: 26408651
Source
Medline
Keywords
License
Unknown

Abstract

Among 205 British South Asian children aged 4-43 months with high incidences of anaemia, iron deficiency, infection and α-thalassaemia, 151 (73.6%) were classified using haemoglobin, MCH, ferritin and CRP values. In 42 non-anaemic, iron-sufficient children with subnormal MCH values, that is with a phenotype of α-thalassaemia trait, RDW, %hypo and ZPP values did not differ significantly from those with iron-deficient erythropoiesis. Raised RDW, %hypo and ZPP values should be interpreted with caution in non-anaemic young British South Asian children with microcytosis.

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