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[Assessment of iron deficiency anemia management in the general hospital of Grenoble: A 12-month follow-up of an intravenous ferric carboxymaltose treatment program in a cohort of patients with non-dialysis-dependent chronic kidney disease].

Authors
  • Romanet, Thierry1
  • Bedouch, Pierrick2
  • Zaoui, Philippe3
  • 1 Service de néphrologie, dialyses, aphérèses, transplantation rénale, CHU Grenoble-Alpes, CS 10 217, 38043 Grenoble cedex 9, France; Pôle pharmacie, pharmacie clinique, secteur soins pharmaceutiques, CHU Grenoble-Alpes, CS 10 217, 38043 Grenoble cedex 9, France. , (France)
  • 2 Pôle pharmacie, pharmacie clinique, secteur soins pharmaceutiques, CHU Grenoble-Alpes, CS 10 217, 38043 Grenoble cedex 9, France. , (France)
  • 3 Service de néphrologie, dialyses, aphérèses, transplantation rénale, CHU Grenoble-Alpes, CS 10 217, 38043 Grenoble cedex 9, France. Electronic address: [email protected] , (France)
Type
Published Article
Journal
Nephrologie & therapeutique
Publication Date
Apr 01, 2019
Volume
15
Issue
2
Pages
104–109
Identifiers
DOI: 10.1016/j.nephro.2018.10.006
PMID: 30803900
Source
Medline
Keywords
Language
French
License
Unknown

Abstract

The FIND-CKD study has validated the use of ferric carboxymaltose (FCM) injection with a target of ferritin level between 400 and 600ng/mL to treat iron deficiency anemia in non-dialysis-dependent chronic kidney disease (ND-CKD) patients. In order to assess this strategy in clinical practice, we constituted a cohort of patients within our nephrology department. Patients had CKD stages 3 to 5, hemoglobin level (Hb)<13g/dL (men) or<12g/dL (women), and ferritin level (F)<100ng/mL or transferrin saturation (TSAT)<20%. They were not treated by erythropoiesis-stimulating agent (ESA) for at least one month, and oral iron had been poorly tolerated or ineffective. FCM first dose was adjusted according to patient weight. A new infusion was possible, at least one month after the first, with a half-dose if TSAT<20% but F≥200ng/mL; no perfusion was performed if F≥400ng/mL. In all, 53 patients were included with a mean Hb of 11.4g/dL and a mean TSAT of 16%. Over one year of follow-up, only 12 patients (22.6%) needed another treatment for anemia (blood transfusion or ESA). No patient showed a significant decrease in Hb. In all, 62% of patients received only one infusion of FCM. The administration of FCM IV with ferritin levels in the recommended target has proven effective in correcting anemia of ND-CKD patients while limiting the use of another therapeutic strategy. Copyright © 2019 Société francophone de néphrologie, dialyse et transplantation. Published by Elsevier Masson SAS. All rights reserved.

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