Affordable Access

Access to the full text

Assessment of inflammatory activity in Crohn’s disease by means of dynamic contrast-enhanced MRI

Authors
  • Pupillo, V. A.1
  • Di Cesare, E.1
  • Frieri, G.2
  • Limbucci, N.1
  • Tanga, M.2
  • Masciocchi, C.1
  • 1 Università degli Studi di L’Aquila, Dipartimento di Diagnostica per Immagini, Via della Mainetta, 88D, Coppito, L’Aquila, I-67010, Italy , Coppito, L’Aquila (Italy)
  • 2 Università degli Studi di L’Aquila, Dipartimento di Gastroenterologia, Via della Mainetta, 88D, Coppito, L’Aquila, I-67010, Italy , Coppito, L’Aquila (Italy)
Type
Published Article
Journal
La radiologia medica
Publisher
Springer Milan
Publication Date
Sep 21, 2007
Volume
112
Issue
6
Pages
798–809
Identifiers
DOI: 10.1007/s11547-007-0192-y
Source
Springer Nature
Keywords
License
Yellow

Abstract

PurposeOur aim was to perform a dynamic study of contrast enhancement of the intestinal wall in patients with Crohn’s disease to quantitatively assess local inflammatory activity.Materials and methodsWe studied a population of 50 patients with histologically proven Crohn’s disease. Magnetic resonance imaging (MRI) was performed using a 1.5-T magnet with a phased-array coil and acquisition of T2-weighted single-shot fast spin echo (SSFSE) half Fourier sequences before intravenous administration of gadolinium, and T1-weighted fast spoiled gradient (FSPGR) fat-saturated sequences before and after contrast administration. Before the examination, patents received oral polyethylene glycol (PEG) (1,000 ml for adults; 10 ml/Kg of body weight for children). Regions of interest (ROI) were placed on the normal and diseased intestinal wall to assess signal intensity and rate of increase in contrast enhancement over time. Data were compared with the Crohn’s Disease Activity Index (CDAI).ResultsThe diseased bowel wall showed early and intense uptake of contrast that increases over time until a plateau is reached. In patients in the remission phase after treatment, signal intensity was only slightly higher in diseased bowel loops than in healthy loops. There was a significant correlation between the peak of contrast uptake and CDAI.ConclusionsDynamic MRI is a good technique for quantifying local inflammatory activity of bowel wall in patients with Crohn’s disease.

Report this publication

Statistics

Seen <100 times