Affordable Access

deepdyve-link
Publisher Website

Assessment of immunotoxicity parameters in individuals occupationally exposed to lead.

Authors
  • García-Lestón, Julia
  • Roma-Torres, Joana
  • Mayan, Olga
  • Schroecksnadel, Sebastian
  • Fuchs, Dietmar
  • Moreira, Ana O
  • Pásaro, Eduardo
  • Méndez, Josefina
  • Teixeira, João Paulo
  • Laffon, Blanca
Type
Published Article
Journal
Journal of toxicology and environmental health. Part A
Publication Date
Jan 01, 2012
Volume
75
Issue
13-15
Pages
807–818
Identifiers
DOI: 10.1080/15287394.2012.690327
PMID: 22788368
Source
Medline
License
Unknown

Abstract

Although adverse health effects produced by lead (Pb) have long been recognized, studies regarding the immunotoxic effects of occupational exposure report conflicting results. In a previous study, alterations in some immunological parameters were noted in 70 Pb-exposed workers. In view of these results, it was of interest to extend this study comprising a larger population and increasing the number of immunological endpoints assessed. Accordingly, in this study the immunotoxic effects of occupational exposure to Pb were assessed by analyzing (1) percentages of lymphocyte subsets (CD3⁺, CD4⁺, CD8⁺, CD19⁺, and CD56⁺/16⁺); (2) concentration of plasma cytokines, namely, interleukin (IL) 2, IL4, IL6, IL10, tumor necrosis factor (TNF) α, and interferon (IFN) γ; and (3) plasma concentrations of neopterin, tryptophan (Trp), and kynurenine (Kyn). In addition, the possible influence of genetic polymorphisms in the vitamin D receptor (VDR) and δ-aminolevulinic acid dehydratase (ALAD) genes on immunotoxicity parameters was studied. Exposed workers showed significant decreases in %CD3⁺, %CD4⁺/%CD8⁺ ratio, IL4, TNFα, IFNγ, and Kyn to Trp ratio (Kyn/Trp), and significant increases in %CD8⁺, IL10, and Trp levels. All these parameters, except Trp, were significantly correlated with exposure biomarkers. No significant influence of genetic polymorphisms was observed. Significant correlation between Kyn/Trp and neopterin concentrations suggests an involvement of indoleamine 2,3-dioxygenase in the Trp metabolic alterations, which may contribute to some of the immune alterations observed. Results obtained suggest that occupational exposure to PB may influence the immune system by impairing several mechanisms, which might ultimately produce deregulation of the immune response and diminish immunosurveillance in exposed individuals.

Report this publication

Statistics

Seen <100 times