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Assessment of Gd-EOB-DTPA-enhanced MRI for HCC and dysplastic nodules and comparison of detection sensitivity versus MDCT

Authors
  • Inoue, Tatsuo1
  • Kudo, Masatoshi1
  • Komuta, Mina2
  • Hayaishi, Sosuke1
  • Ueda, Taisuke1
  • Takita, Masahiro1
  • Kitai, Satoshi1
  • Hatanaka, Kinuyo1
  • Yada, Norihisa1
  • Hagiwara, Satoru1
  • Chung, Hobyung1
  • Sakurai, Toshiharu1
  • Ueshima, Kazuomi1
  • Sakamoto, Michiie2
  • Maenishi, Osamu3
  • Hyodo, Tomoko4
  • Okada, Masahiro4
  • Kumano, Seishi4
  • Murakami, Takamichi4
  • 1 Kinki University Faculty of Medicine, Division of Gastroenterology and Hepatology, Department of Internal Medicine, 377-2 Ohno-Higashi, Osaka-Sayama, Osaka, 589-8511, Japan , Osaka-Sayama (Japan)
  • 2 Keio University Faculty of Medicine, Department of Pathology, 35 Shinanomachi, Shinjyuku-ku, Tokyo, 160-8582, Japan , Tokyo (Japan)
  • 3 Kinki University Faculty of Medicine, Department of Pathology, 377-2 Ohno-Higashi, Osaka-Sayama, Osaka, 589-8511, Japan , Osaka-Sayama (Japan)
  • 4 Kinki University Faculty of Medicine, Department of Radiology, 377-2 Ohno-Higashi, Osaka-Sayama, Osaka, 589-8511, Japan , Osaka-Sayama (Japan)
Type
Published Article
Journal
Journal of Gastroenterology
Publisher
Springer Japan
Publication Date
Apr 17, 2012
Volume
47
Issue
9
Pages
1036–1047
Identifiers
DOI: 10.1007/s00535-012-0571-6
Source
Springer Nature
Keywords
License
Yellow

Abstract

BackgroundWe aimed to evaluate gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd-EOB-DTPA)-enhanced magnetic resonance imaging (MRI) for the detection of hepatocellular carcinomas (HCCs) and dysplastic nodules (DNs) compared with dynamic multi-detector row computed tomography (MDCT), and to discriminate between HCCs and DNs.MethodsEighty-six nodules diagnosed as HCC or DNs were retrospectively investigated. Gd-EOB-DTPA-enhanced MRI and dynamic MDCT were compared with respect to their diagnostic ability for hypervascular HCCs and detection sensitivity for hypovascular tumors. The ability of hepatobiliary images of Gd-EOB-DTPA-enhanced MRI to discriminate between these nodules was assessed. We also calculated the EOB enhancement ratio of the tumors.ResultsFor hypervascular HCCs, the diagnostic ability of Gd-EOB-DTPA-enhanced MRI was significantly higher than that of MDCT for tumors less than 2 cm (p = 0.048). There was no difference in the detection of hypervascular HCCs between hepatobiliary phase images of Gd-EOB-DTPA-enhanced MRI (43/45: 96%) and dynamic MDCT (40/45: 89%), whereas the detection sensitivity of hypovascular tumors by Gd-EOB-DTPA-enhanced MRI was significantly higher than that by dynamic MDCT (39/41: 95% vs. 25/41: 61%, p = 0.001). EOB enhancement ratios were decreased in parallel with the degree of differentiation in DNs and HCCs, although there was no difference between DNs and hypovascular well-differentiated HCCs.ConclusionThe diagnostic ability of Gd-EOB-DTPA-enhanced MRI for hypervascular HCCs less than 2 cm was significantly higher than that of MDCT. For hypovascular tumors, the detection sensitivity of hepatobiliary phase images of Gd-EOB-DTPA-enhanced MRI was significantly higher than that of dynamic Gd-EOB-DTPA-enhanced MRI and dynamic MDCT. It was difficult to distinguish between DNs and hypovascular well-differentiated HCCs based on the EOB enhancement ratio.

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