The French concept of “Ecocompatibility” is defined as the situation where the pollutant flux from waste either disposed of or used in specified conditions (physical, hydrogeological, physico-chemical and biological conditions) is compatible with the environmental acceptance of the concerned receptor cells. The chief feature of this definition is to integrate the evaluation of the three following terms: pollutants emission from the waste (source term), transport of the pollutants from the waste to the receptor cells (transport term) and the environmental acceptance of receptor cells (impact term).The specific objectives of our paper are the introduction of a methodology for the assessment of the Ecocompatibility of waste disposal or waste reuse scenarios and to develop the experimental part of this methodology: laboratory measurements and tests.First, we introduce the various terms of the methodology. We briefly present a literature survey carried out by 9 research teams consisting of a state of the art on the knowledge and the tools available for the study of each determined term. This work particularly resulted in the identification of influence factors and characteristic parameters to be considered for a relevant assessment of waste ecocompatibility. An experimental programme (field and laboratory scale) followed the literature survey. It aimed to apply the methodology on 3 theoretical scenarios in view of the final methodology elaboration. Finally, we introduce the various steps of the defined methodology and conclude with its application limits.