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Assessment of biological activity of novel peptide analogues of angiotensin IV.

Authors
  • Gard, Paul R
  • Olivier, George
  • Golding, Bruno
  • Bourner, Claire
  • Dang, Tony
  • Haliru, Haliru
  • Higgins, Eleanor
  • Kimberley, Helen
  • Loginova, Olga
  • Madhavi, Shahnaz
  • Ryan, Denis
Type
Published Article
Journal
Journal of Pharmacy and Pharmacology
Publisher
Wiley
Publication Date
Apr 01, 2011
Volume
63
Issue
4
Pages
565–571
Identifiers
DOI: 10.1111/j.2042-7158.2010.01247.x
PMID: 21401609
Source
Medline
License
Unknown

Abstract

This study provides five novel inhibitors of IRAP worthy of assessment in behavioural models of learning and memory. The analogues are devoid of AT(1) receptor agonist properties, and the carboxyamide analogue presents an opportunity to elucidate the mechanism of action of Ang IV as, like Ang IV, it inhibits IRAP, but antagonises the effects of Ang IV on isolated smooth muscle.

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