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Assessing interactions for fixed-dose drug combinations in tumor xenograft studies.

Authors
  • Wu, Jianrong
  • Tracey, Lorraine
  • Davidoff, Andrew M
Type
Published Article
Journal
Journal of Biopharmaceutical Statistics
Publisher
Informa UK (Taylor & Francis)
Publication Date
Jan 01, 2012
Volume
22
Issue
3
Pages
535–543
Identifiers
DOI: 10.1080/10543406.2011.556285
PMID: 22416839
Source
Medline
License
Unknown

Abstract

Statistical methods for assessing the joint action of compounds administered in combination have been established for many years. However, there is little literature available on assessing the joint action of fixed-dose drug combinations in tumor xenograft experiments. Here an interaction index for fixed-dose two-drug combinations is proposed. Furthermore, a regression analysis is also discussed. Actual tumor xenograft data were analyzed to illustrate the proposed methods.

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