Affordable Access

deepdyve-link
Publisher Website

Assessing the economic merits of managing cytomegalovirus infection in organ and stem cell transplantation.

Authors
  • Wait, Suzanne
  • Musingarimi, Primrose
  • Briggs, Andrew
  • Tillotson, Glenn
Type
Published Article
Journal
Journal of Medical Economics
Publisher
Informa UK Limited
Publication Date
Mar 01, 2009
Volume
12
Issue
1
Pages
68–76
Identifiers
DOI: 10.3111/13696990902855019
PMID: 19450067
Source
Medline
License
Unknown

Abstract

Two preventative approaches exist to manage cytomegalovirus (CMV), a common infection in recipients of organ and stem cell transplants: prophylaxis--the prevention of viraemia--and pre-emptive therapy--the prevention of manifestation of disease in patients who have viraemia. Economic evaluation may provide a helpful framework to inform the choice between these two approaches. However, several issues arise. Direct comparisons of prophylaxis and pre-emptive therapy are rare and there are few epidemiological data that depict the full natural history of CMV infection and disease. There is a need for large, prospective randomised trials that directly compare these two strategies and are of sufficient duration to assess their overall impact on direct and indirect effects of CMV as well as patient quality of life. These methodological issues are relevant to the economic evaluation of preventative measures in other clinical settings and highlight the need for a rigorous evaluative framework to best inform decision making about the optimal strategy for patients.

Report this publication

Statistics

Seen <100 times