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Assessing the challenges of Fourier transform infrared spectroscopic analysis of blood serum.

Authors
  • Hughes, Caryn
  • Brown, Michael
  • Clemens, Graeme
  • Henderson, Alex
  • Monjardez, Geraldine
  • Clarke, Noel W
  • Gardner, Peter
Type
Published Article
Journal
Journal of Biophotonics
Publisher
Wiley (John Wiley & Sons)
Publication Date
Apr 01, 2014
Volume
7
Issue
3-4
Pages
180–188
Identifiers
DOI: 10.1002/jbio.201300167
PMID: 24488587
Source
Medline
Keywords
License
Unknown

Abstract

There are many approaches to measuring the infrared spectrum of a blood serum sample. Naturally, each approach will have both advantages and disadvantages. We report on the progress of the application of infrared spectroscopy in the field of blood serum analysis towards clinical application, with a focus on prostate cancer. In order to perform a high-powered study with clinical relevance, choosing the most suitable approach must undergo careful consideration. We review the possibilities of using different sample preparation methods and speculate upon the potential pitfalls of both transmission and attenuated total reflectance (ATR) techniques.

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