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Assessing Causality Between Childhood Adiposity and Early Puberty: A Bidirectional Mendelian Randomization and Longitudinal Study.

Authors
  • Chen, Yang-Ching1
  • Fan, Hsien-Yu2
  • Yang, Chen3
  • Hsieh, Rong-Hong4
  • Pan, Wen-Harn5
  • Lee, Yungling L6
  • 1 Department of Family Medicine, Taipei Medical University Hospital, Taipei, Taiwan; Department of Family Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan; School of Nutrition and Health Sciences, College of Nutrition, Taipei Medical University, Taipei, Taiwan; Graduate Institute of Metabolism and Obesity Sciences, Taipei Medical University, Taipei, Taiwan. , (Taiwan)
  • 2 Department of Family Medicine, Taipei Medical University Hospital, Taipei, Taiwan; Institute of Epidemiology and Preventive Medicine, National Taiwan University, Taipei, Taiwan. , (Taiwan)
  • 3 Department of Pediatrics, Taipei Medical University, Hospital, Taipei Medical University, Taipei, Taiwan. , (Taiwan)
  • 4 School of Nutrition and Health Sciences, College of Nutrition, Taipei Medical University, Taipei, Taiwan. , (Taiwan)
  • 5 Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan. , (Taiwan)
  • 6 Institute of Epidemiology and Preventive Medicine, National Taiwan University, Taipei, Taiwan; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan. Electronic address: [email protected] , (Taiwan)
Type
Published Article
Journal
Metabolism: clinical and experimental
Publication Date
Aug 15, 2019
Pages
153961–153961
Identifiers
DOI: 10.1016/j.metabol.2019.153961
PMID: 31422054
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Obesity and early puberty have been reported to be mutually causative. We investigated the causal relationship between adiposity and early puberty by performing bidirectional Mendelian randomization (MR) and longitudinal data analyses. We used information from the Taiwan Children Health Study (3109 adolescents aged 11-12 years) with 17 body mass index (BMI)- and 10 puberty-related single-nucleotide polymorphisms (SNPs) to produce genetic instrumental variables (IVs). The two-stage least squares (2SLS) method, MR sensitivity analysis, and survival analysis were used to explore and confirm causality. Regression estimates from IVs revealed that significantly increased association of BMI with early puberty was noted. (coefficients: 0.13, 0.10, and 0.09; 95% CI: 0.07-0.19, 0.02-0.19, and 0.02-0.16 for all participants, male adolescents, and female adolescents, respectively). Genetic IVs for puberty were not associated with BMI. MR sensitivity and two-sample MR analyses produced similar results. Longitudinal analysis results revealed that prepubertal overweight and obesity could predict early onset of puberty. However, after excluding children with a history of overweight and obesity at the age of 7-12 years, early puberty was not found to trigger new-onset of overweight and obesity at the age of 18 years in either sex. Higher adiposity may lead to early puberty. However, the causal effects of early puberty on adiposity accumulation was not supported by our data. Targeted interventions to reduce childhood obesity are strongly recommended to prevent obesity-related comorbidities, as well as early puberty onset. Copyright © 2019. Published by Elsevier Inc.

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