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Assembly of ribosomal subunits affected in a ribosomal mutant of E. coli having an altered L22 protein.

Authors
  • Pardo, D
  • Vola, C
  • Rosset, R
Type
Published Article
Journal
Molecular & general genetics : MGG
Publication Date
Jul 02, 1979
Volume
174
Issue
1
Pages
53–58
Identifiers
PMID: 384161
Source
Medline
License
Unknown

Abstract

In this article we describe some in vivo properties of a coldsensitive ribosomal mutant from Escherichia coli. The mutation affects the rplV gene which is the structural gene of ribosomal protein L22. Our work shows that at 22 degrees C, the biosynthesis of both ribosomal subunits and the maturation processing of 15S and 23S ribosomal RNA are impaired. Integration of our results in a general model of in vivo ribosomal assembly in E. coli is presented.

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