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Assembling the puzzle of anti-cancer mechanisms triggered by cardiac glycosides

Authors
Type
Published Article
Journal
Mitochondrion
Publisher
Elsevier
Publication Date
May 23, 2013
Volume
13
Issue
3
Pages
234–234
Identifiers
DOI: 10.1016/j.mito.2012.06.003
Source
LBMCC
Keywords
License
Green

Abstract

Cardiac glycosides (CGs) are compounds used for the treatment of cardiac failure which also display strong anti-cancer activity inducing impairment of cell proliferation or activation of cell death whether by apoptosis or autophagy. Despite the fact that the sodium/potassium (Na(+)/K(+))-ATPase is a well-known target of CGs, its involvement in the anti-cancer effect of these compounds remains to be validated. Importantly, related intracellular sensor(s)/transducer(s) needs further characterization. We will discuss here key mechanisms activated by CGs including their ability to modulate the cell cycle and to regulate the expression of anti-apoptotic Bcl-2 family members, two so far marginally investigated events.

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