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Assay of HBV DNA in the plasma of HBV-carrier chimpanzees superinfected with non-A, non-B hepatitis.

Authors
  • Harrison, T J
  • Tsiquaye, K N
  • Zuckerman, A J
Type
Published Article
Journal
Journal of Virological Methods
Publisher
Elsevier
Publication Date
May 01, 1983
Volume
6
Issue
5
Pages
295–302
Identifiers
PMID: 6409916
Source
Medline
License
Unknown

Abstract

A dot hybridisation technique was used to monitor the levels of hepatitis B virus (HBV) DNA in the plasma of two HBV-carrier chimpanzees which had been inocula ed with documented infectious non-A, non-B hepatitis agents. A marked decrease in the quantity of HBV DNA in the plasma during the acute phase of the non-A, non-B hepatitis was observed in both carriers. The possible role of interferon or a similar antiviral agent in modulation of the HBV-carrier state is discussed. Hybridisation may become, in due course, the method of choice for examining blood samples for infectious hepatitis B virus.

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