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Aspartame metabolism in normal adults, phenylketonuric heterozygotes, and diabetic subjects.

Authors
Type
Published Article
Journal
Diabetes Care
0149-5992
Publisher
American Diabetes Association
Publication Date
Volume
12
Issue
1
Pages
67–74
Identifiers
PMID: 2653751
Source
Medline
License
Unknown

Abstract

This study reviews clinical studies testing the effects of various doses of aspartame on blood levels of phenylalanine, aspartate, and methanol in normal subjects and known phenylketonuric heterozygotes. The effect of aspartame on the phenylalanine-to-large neutral amino acid ratio under various feeding situations is shown. The clinical studies of aspartame in diabetic subjects are limited to observations of its effects on blood levels of glucose, lipids, insulin, and glucagon. These studies clearly demonstrate the safety of this high-intensity sweetener for use by humans.

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