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Ascorbate oxidation is a prerequisite for its transport into rat liver microsomal vesicles.

Authors
  • M Csala
  • V Mile
  • A Benedetti
  • J Mandl
  • G Bánhegyi
Publication Date
Jul 15, 2000
Source
PMC
Keywords
License
Unknown

Abstract

Oxidation and uptake of ascorbate show similar time courses in rat liver microsomal vesicles: a rapid burst phase is followed by a slower process. Inhibitors of ascorbate oxidation (proadifen, econazole or quercetin) also effectively decreased the uptake of ascorbate. The results show that dehydroascorbate is the transport form of ascorbate at the membrane of the endoplasmic reticulum.

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