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The Aryl Hydrocarbon Receptor (AhR) Mediates the Counter-Regulatory Effects of Pelargonidins in Models of Inflammation and Metabolic Dysfunctions

Authors
  • biagioli, michele
  • carino, adriana
  • fiorucci, chiara
  • annunziato, giannamaria
  • marchianò, silvia
  • bordoni, martina
  • roselli, rosalinda
  • di giorgio, cristina
  • castiglione, federica
  • ricci, patrizia
  • bruno, agostino
  • faccini, andrea
  • distrutti, eleonora
  • baldoni, monia
  • costantino, gabriele
  • fiorucci, stefano
Publication Date
Aug 07, 2019
Identifiers
DOI: 10.3390/nu11081820
OAI: oai:mdpi.com:/2072-6643/11/8/1820/
Source
MDPI
Keywords
Language
English
License
Green
External links

Abstract

, Ifn-ƴ, and Il-6, while promoted the expansion of regulatory T cells and M2 macrophages. In C57BL/6J mice fed a high fat diet (HFD), Mt-P attenuated body weight gain, intestinal and liver inflammation, and ameliorated insulin sensitivity, while worsened liver steatosis by up-regulating the liver expression of Cd36 and Apo100b. These effects were abrogated by AhR gene ablation. Mt-P is a synthetic pelargonidin endowed with robust AhR agonist activity that exerts beneficial effects in murine models of inflammation and metabolic dysfunction.

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