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Artificially decreasing cortical tension generates aneuploidy in mouse oocytes

Authors
  • Bennabi, Isma1
  • Crozet, Flora1
  • Nikalayevich, Elvira1
  • Chaigne, Agathe2
  • Letort, Gaëlle1
  • Manil-Ségalen, Marion1
  • Campillo, Clément3
  • Cadart, Clotilde4, 5
  • Othmani, Alice6
  • Attia, Rafaele4, 5
  • Genovesio, Auguste6
  • Verlhac, Marie-Hélène1
  • Terret, Marie-Emilie1
  • 1 CIRB, Collège de France, UMR7241/U1050, Paris, 75005, France , Paris (France)
  • 2 MRC Laboratory for Molecular Cell Biology, UCL, London, WC1E 6BT, UK , London (United Kingdom)
  • 3 LAMBE, Université d’Evry val d’Essonne, Evry, UMR 8587, France , Evry (France)
  • 4 Institut Curie, PSL Research University, CNRS, UMR 144, Paris, F-75005, France , Paris (France)
  • 5 PSL Research University, Paris, F-75005, France , Paris (France)
  • 6 IBENS, Ecole Normale Supérieure, UMR8197/U1024, Paris, 75005, France , Paris (France)
Type
Published Article
Journal
Nature Communications
Publisher
Springer Nature
Publication Date
Apr 03, 2020
Volume
11
Issue
1
Identifiers
DOI: 10.1038/s41467-020-15470-y
Source
Springer Nature
License
Green

Abstract

The developmental potential of human and murine oocytes is predicted by their mechanical properties. Here the authors show that artificial reduction of cortex tension produces aneuploid mouse oocytes and speculate that this may contribute to the high aneuploidy rate typical of female meiosis.

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