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Artificial receptor-facilitated solid-phase microextraction of barbiturates.

Authors
  • Li, S
  • Sun, L
  • Chung, Y
  • Weber, S G
Type
Published Article
Journal
Analytical chemistry
Publication Date
Jun 01, 1999
Volume
71
Issue
11
Pages
2146–2151
Identifiers
DOI: 10.1021/ac980587o
PMID: 21662750
Source
Medline
License
Unknown

Abstract

A receptor for barbiturates, N,N'-Bis-[6-(2-ethylhexanoylamino)-pyridin-2-yl]-isophthalamide, was designed to dissolve in plasticizers of poly(vinyl chloride) (PVC). Microextractions using receptor-doped films of PVC were carried out as a function of receptor concentration. The effect of the concentration of the receptor on extraction yield is considerable for barbiturates that have significant binding to the receptor but negligible for very similar molecules that do not bind to the receptor strongly. Thus, it is the receptor's ability in molecular recognition, not its generic ability as an H-bonding cosolvent, that is important. On the other hand, NMR data show that the receptor self-associates. A simple, approximate analysis is given to extract the amount of active receptor from the data. Receptor-enhanced extractions of barbiturates from urine are compared to extractions using a phosphate ester as solvent.

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