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Artificial Elimination of Drug Resistance from Group A Beta-Hemolytic Streptococci

Authors
  • Masataka Nakae
  • Matsuhisa Inoue
  • Susumu Mitsuhashi
Publication Date
May 01, 1975
Source
PMC
Keywords
License
Unknown

Abstract

Ten strains of beta-hemolytic streptococci were tested for elimination of resistance to macrolide antibiotics, tetracycline, and chloramphenicol. Six of the strains lost resistance after cultivation at 41 C or addition of acriflavine (0.2 μg/ml). These results suggest that determinants governing resistance to these antibiotics are located on extrachromosomal genetic elements (plasmids) that are widely distributed in streptococci.

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