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Articular chondrocyte network mediated by gap junctions: role in metabolic cartilage homeostasis.

Authors
  • Mayan, Maria D1
  • Gago-Fuentes, Raquel1
  • Carpintero-Fernandez, Paula1
  • Fernandez-Puente, Patricia2
  • Filgueira-Fernandez, Purificacion3
  • Goyanes, Noa3
  • Valiunas, Virginijus4
  • Brink, Peter R4
  • Goldberg, Gary S5
  • Blanco, Francisco J6
  • 1 Rheumatology Division, Cartilage Biology Research Group, INIBIC-Hospital Universitario A Coruña, A Coruña, Spain.
  • 2 Rheumatology Division, ProteoRed/ISCIII, Proteomics Group, INIBIC-Hospital Universitario A Coruña, A Coruña, Spain.
  • 3 Rheumatology Division, CIBER-BBN/ISCIII, INIBIC-Hospital Universitario A Coruña, A Coruña, Spain.
  • 4 Department of Physiology and Biophysics, State University of New York, Stony Brook, New York, USA.
  • 5 Department of Molecular Biology, Medical Center Drive, University of Medicine and Dentistry of New Jersey, Stratford, New Jersey, USA.
  • 6 Rheumatology Division, Cartilage Biology Research Group, INIBIC-Hospital Universitario A Coruña, A Coruña, Spain Rheumatology Division, ProteoRed/ISCIII, Proteomics Group, INIBIC-Hospital Universitario A Coruña, A Coruña, Spain Rheumatology Division, CIBER-BBN/ISCIII, INIBIC-Hospital Universitario A Coruña, A Coruña, Spain.
Type
Published Article
Journal
Annals of the Rheumatic Diseases
Publisher
BMJ
Publication Date
January 2015
Volume
74
Issue
1
Pages
275–284
Identifiers
DOI: 10.1136/annrheumdis-2013-204244
PMID: 24225059
Source
Medline
Keywords
License
Unknown

Abstract

This study reveals that intercellular connections between chondrocytes contain GJs that play a key role in cell-cell communication and a metabolic function by exchange of nutrients including glucose and essential amino acids. A three-dimensional cellular network mediated through GJs might mediate metabolic and physiological homeostasis to maintain cartilage tissue.

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