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Arsenic-containing hydrocarbons are toxic in the in vivo model Drosophila melanogaster.

Authors
  • Meyer, S
  • Schulz, J
  • Jeibmann, A
  • Taleshi, M S
  • Ebert, F
  • Francesconi, K A
  • Schwerdtle, T
Type
Published Article
Journal
Metallomics : integrated biometal science
Publication Date
Nov 01, 2014
Volume
6
Issue
11
Pages
2010–2014
Identifiers
DOI: 10.1039/c4mt00249k
PMID: 25292248
Source
Medline
License
Unknown

Abstract

Arsenic-containing hydrocarbons (AsHC) constitute one group of arsenolipids that have been identified in seafood. In this first in vivo toxicity study for AsHCs, we show that AsHCs exert toxic effects in Drosophila melanogaster in a concentration range similar to that of arsenite. In contrast to arsenite, however, AsHCs cause developmental toxicity in the late developmental stages of Drosophila melanogaster. This work illustrates the need for a full characterisation of the toxicity of AsHCs in experimental animals to finally assess the risk to human health related to the presence of arsenolipids in seafood.

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