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Array-CGH and multipoint FISH to decode complex chromosomal rearrangements.

Authors
  • Darai-Ramqvist, Eva
  • Diaz de Ståhl, Teresita
  • Sandlund, Agneta
  • Mantripragada, Kiran
  • Klein, George
  • Dumanski, Jan
  • Imreh, Stefan
  • Kost-Alimova, Maria
Type
Published Article
Journal
BMC Genomics
Publisher
Springer (Biomed Central Ltd.)
Publication Date
Jan 01, 2006
Volume
7
Pages
330–330
Identifiers
PMID: 17196103
Source
Medline
License
Unknown

Abstract

In most cases, the changes in copy number seen on array-CGH profiles reflected cumulative chromosome rearrangements. Most of them stemmed from unbalanced translocations. Although our chr3 BAC/PAC array could identify single copy number changes even in pentaploid cells, mpFISH provided a more accurate analysis in the dissection of complex karyotypes at high ploidy levels.

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