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Aromatic polyketides from a sponge-derived fungus Metarhizium anisopliae mxh-99 and their antitubercular activities.

Authors
  • Kong, Xianglan1
  • Ma, Xinhua
  • Xie, Yunying
  • Cai, Shengxin
  • Zhu, Tianjiao
  • Gu, Qianqun
  • Li, Dehai
  • 1 Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, People's Republic of China. , (China)
Type
Published Article
Journal
Archives of pharmacal research
Publication Date
Jun 01, 2013
Volume
36
Issue
6
Pages
739–744
Identifiers
DOI: 10.1007/s12272-013-0077-7
PMID: 23463335
Source
Medline
License
Unknown

Abstract

In our screening for antitubercular agents, five naphtho-γ-pyrones including two new naphtho-γ-pyrones glycosides, indigotides G and H (1 and 2), and two diphenyl ethers were isolated from the extract of a sponge-derived fungus Metarhizium anisopliae mxh-99. Their structures were established on the basis of chemical and spectroscopic evidence. The antitubercular activities of all the compounds were evaluated against Mycobacterium phlei. The known isochaetochromin B2 (6) and ustilaginoidin D (7) exhibited the highest activity with MICs 50.0 μg/mL.

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